Children's Brain Tumour Research Centre
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Name
Dr. Ruman Rahman
Qualifications
PhD, BSc (Hons)
Position
Research Fellow
School/Division
Child Health
Contact
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| Email: | ruman.rahman@nottingham.ac.uk |
| Web: | http://www.cbtrc.org/ruman_rahman.htm |
Research interests
Telomere and Telomerase Biology in Paediatric Brain Tumours
Biological basis of cancer progression with respect to telomeres and telomerase.
Prognostic biologic markers in Ependymoma, sPNET, Medulloblastoma and GBM.
Brain Cancer Stem Cells
Telomeres and telomerase in tumour initiating cells and non-tumourigenic progeny.
Drug Resistance in tumour stem cells.
Recent publications
Rahman R, Mo L, Cui W (2006). Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth. Biochem. Biophys Res Commun 350:796-802.
Rahman R, Forsyth NR, Cui W (2007). Telomeric 3’-Overhang Length is Associated with the Size of Telomeres. (Manuscript Submitted to Ageing Cell).
Ridley L, Rahman R et al (2007). Multifactorial Analysis of Predictors of Outcome in Paediatric Intracranial Ependymoma. (Manuscript in preparation).
Tai G, Rahman R et al (2007). Aneuploid transformation of human embryonic stem cell derivatives during in vitro expansion is associated with oxidative DNA damage and immortalization by telomerase. (Manuscript in preparation).