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Dr. Ruman Rahman

Name

Dr. Ruman Rahman

Qualifications

PhD, BSc (Hons)

Position

Research Fellow

School/Division

Child Health

Contact

Phone:  
Fax:  
Email: ruman.rahman@nottingham.ac.uk
Web: http://www.cbtrc.org/ruman_rahman.htm

Research interests

Development of novel 3D childhood brain tumour models to better mimic in vivo tumour physiology and for the evaluation of chemotherapeutic agents.

 

Efficacy of chemotherapeutic agents against brain tumour stem cells

 

Histone deacetylase inhibition and G-quadruplex stabilization as a mode of telomerase inhibition in childhood brain tumours.

 

Recent publications

Rahman R, Osteso-Ibanez T, Hirst R, Levesley J, Quinn S, O’Callaghan C, Coyle B, Grundy R. Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high grade paediatric brain tumour cells.  Molecular Cancer Therapeutics. (Article in press).

Rahman R, Smith S, Rahman C, Grundy R. Anti-angiogenic therapy and mechanisms of tumour resistance in malignant glioma. Journal of Oncology (2010) doi:10.1155/2010/251231 May 2010.

Hussein D, Punjaruk W, Storer L, Shaw L, Ottoman R, Peet A, Miller .....Rahman R......Coyle B. Characterisation of the cancer stem cell component of seven primary paediatric brain tumour cell lines 2010. (Accepted in Neuro-oncology).

Rahman R, Kilday J-P, Ridley L, Lowe J, Rand V, Grundy R. Pediatric ependymoma: Biological perspectives. Molecular Cancer Research (2009) 7(6):765-786..

Rahman R, Heath R, Grundy R. Cellular immortality in brain tumours: An integration of the cancer stem cell paradigm. Biochimica et Biophysica Acta – Molecular Basis of Disease (2009) 1792: 280-288..

Rahman R, Ridley L, Brundler M-A et al. Multifactorial analysis of predictors of outcome in paediatric intracranial ependymoma. Neuro-oncology (2008) 10: 675-689.

Rahman R, Forsythe N, Cui W. Telomeric 3'-overhang length is associated with the size of telomeres. Experimental Gerontology (2008) 43: 258-65.

 

Rahman R, Mo L, Cui W.  Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth.
Biochemical and Biophysical Research Communications (2006) 350: 796-802.