Our profiles

Name

Prof. Richard Grundy

Qualifications

BSc PhD MBChB MRCP FRCPCH

Position

Professor of Paediatric Neuro-Oncology and Cancer Biology

School/Division

Child Health

Contact

Phone: +44 (0) 115 8230620
Fax:  
Email: richard.grundy@nottingham.ac.uk
Web: http://www.cbtrc.org/richard_grundy

Research interests

It is clear that improvement in our ability to cure children with brain tumours and reduce the considerable morbidity will only come through a better understanding of the underlying biology of these varied and presently difficult to treat tumours. The principal aim of my research is based on this philosophy. Our research programme includes the use of DNA and RNA microarray technologies to identify biological correlates of tumour behaviour; to elucidate the underlying  molecular alterations of each tumour type and to validate novel targets for the development of new drug therapies. In addition to my research activities at the Children’s Brain Tumour Research centre, I also have an active interest in the development and conduct of clinical trials in CNS tumours and am a long standing member of the Children’s Cancer Leukaemia Group CNS division. I am Chief investigator of the International Society of Paediatric Oncology Ependymoma study and heavily involved in discussions over the next Ependymoma trial. I am also Chair of the Biology Committee of the UK Paediatric Brain Tumour Consortium and am a Co-Investigator on a number of Children’s Cancer Leukaemia, Group Clinical and Biological studies.

Recent publications

Grundy R, Wilne S, Weston C, Robinson K, Lashford L, Ironside J, et al

(2007). Primary post-operative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG/SIOP prospective study. Lancet Oncology. 8:696-705.

 

Wilne S, Collier J, Kennedy C, Koller K, Grundy R, Walker D (2007). Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncology. 8:685-95.

 

Peet A, Lateef S, Macpherson L, Natarajan K, Sgouros S, Grundy R (2007). Short echo time 1 H magnetic resonance spectroscopy of childhood brain tumours. Childs Nervous System. 2007;23:163-9.

 

Kombogiorgas D, Sgouros S, Walsh A, Hockley A, Stevens M, Grundy R, et al. Outcome of children with posterior fossa medulloblastoma: a single institution experience over the decade 1994-2003 (2007). Childs Nervous System.23(4):399-405.

 

Sharif K, Ramani P, Lochbuhler H, Grundy R, de Ville de Goyet J (2006). Recurrent mesenchymal hamartoma associated with 19q translocation.  A call for more radical surgical resection. European Journal of Pediatric Surgery. 16(1):64-7.

 

Wilne S, Collier J, Walker D, Grundy R, Kennedy C, Punt J (2005). The presentation of childhood brain tumors: A meta-analysis. Neuro-Oncology. 7(3):335.