Children's Brain Tumour Research Centre

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Key publications

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Pajtler KW, …, Grundy RG, et al. The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants. Acta Neuropathol. 2017 Jan;133(1):5-12. doi: 10.1007/s00401-016-1643-0.

Veldhuijzen van Zanten SE, …, Grundy R, et al; Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. J Neurooncol. 2017 Jan 21. doi: 10.1007/s11060-016-2363-y

Rogers H, Estranero J, Gudka K, Grundy RG. The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors. Oncotarget 2017; 8(2): 2083-95

Chu T, Shah A, Walker D, Coleman M. Where are the opportunities for an earlier diagnosis of primary intracranial tumours in children and young adults? European Journal of Paediatric Neurology 2017; 21(2): 388-95.




Solanki S, MacCormac O, Dow G, Smith S. Malignant transformation of residual posterior fossa epidermoid cyst to squamous cell carcinoma. British Journal of Neurosurgery 2016.

Ramsawhook A, Lewis L, Coyle B, Ruzov A. Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression. Clinical Epigenetics 2016; 9(18).

Nailor A, Walker D, Jacques TS, et al. Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours. eCancer 2016.

Meng W, Garnett M, Walker D. Penetration and intracellular uptake of poly(glycerol-adipate) nanoparticles into three-dimensional brain tumour cell culture models. Experimental Biology & Medicine 2016; 241(5): 466-77.

Ivanov DP, Coyle B, Walker D, Grabowska A. In vitro models of medulloblastoma: Choosing the right tool for the job. Journal of biotechnology 2016; 236: 10-25.

HeadSmart: Be Brain Tumour Aware, Walker D. A new clinical guideline from the Royal College of Paediatrics & Child Health with a national awareness campaign accelerates brain tumor diagnosis in UK childre - 'HeadSmart: Be Brain Tumour Aware'. Neuro Oncology 2016; 18(3): 445-54.

Gudrunardottir T, Morgan A, Lux A, et al. Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results. Childs Nerv Syst 2016; 32: 1195-203.

English M, Grundy R, Peet A, Lowis S, Walker D. Proton beam therapy for medulloblastoma. Lancet Oncol 2016; 17(5).

Al-Ghafari A, Punjaruk W, Storer L, et al. Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro Oncology 2016; 127: 455-62.

Brain tumour call. The Times. 2016 12 April 2016.

Torchia J, …., Grundy RG, et al. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell. 2016 Dec 12;30(6):891-908. doi: 10.1016/j.ccell.2016.11.003.

Thomas C, …, Grundy RG, et al. Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol. 2016 Jun;18(6):790-6. doi: 10.1093/neuonc/nov322.

Veldhuijzen van Zanten SE, van Meerwijk CL, Jansen MH, Twisk JW, Anderson AK, Coombes L, Breen M, Hargrave OJ, Hemsley J, Craig F, Cruz O, Kaspers GJ, van Vuurden DG, Hargrave DR; SIOPE DIPG Network. Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey.
Neuro Oncol. 2016 Apr;18(4):582-8. doi: 10.1093/neuonc/nov250.




Zhang W, Yu Y, Hertwig F, et al. Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Genome biology 2015; 16: 133.

Vivekanandan S, Breene R, Ramanujachar R, et al. The UK experience of a treatment strategy for pediatric metastatic medulloblastoma comprising intensive induction chemotherapy, hyperfractionated accelerated radiotherapy and response directed high dose myeloablative chemotherapy or maintenance chemotherapy (Milan Strategy). Pediatic Blood Cancer 2015; 62(12): 2132-9.

Torchia J, Picard D, Lafay-Cousin L, et al. Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis. Lancet Oncol 2015; 16(5): 569-82. 

Smith SJ, Ward JH, Tan C, Grundy RG, Rahman R. Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response. Oncotarget 2015.

Shlien A, Campbell BB, de Borja R, et al. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nat Genet 2015; 47(3): 257-62.

Lourdusamy A, Rahman R, Smith S, Grundy R. microRNA network analysis identifies miR-29 cluster as key regulator of LAMA2 in ependymoma. Acta neuropathologica communications 2015; 3: 26.

Lourdusamy A, Rahman R, Grundy RG. Expression alterations define unique molecular characteristics of spinal ependymomas. Oncotarget 2015.

Ivanov DP, Parker TL, Walker DA, et al. In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment. Journal of biotechnology 2015.

Grech-Sollars M, Hales PW, Miyazaki K, et al. Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain. NMR Biomed 2015; 28(4): 468-85.

Fetit AE, Novak J, Rodriguez D, et al. 3D Texture Analysis of Heterogeneous MRI Data for Diagnostic Classification of Childhood Brain Tumours. Studies in health technology and informatics 2015; 213: 19-22.

Coyle B, Kessler M, Sabnis D, Kerr ID. ABCB1 in children's brain tumours. Biochem Soc Trans 2015; 43(5): 1018-22.
Chu TP, Shah A, Walker D, Coleman MP. Pattern of symptoms and signs of primary intracranial tumours in children and young adults: a record linkage study. Arch Dis Child 2015.




Wilne S, Walker D. Could this child have a brain tumour? Signs and symptoms. British Journal of School Nursing 2014 (In Press); 9(3): 78-82.

Walker DA, Chu T, Shah A, S WI, Coleman M. A new clinical guideline (2007) and national awareness campaign (2011) accelerated brain tumour diagnosis in uk children (headsmart - be brain tumour aware). Neuro Oncol 2014; 16 Suppl 3: iii2.

Walker D, Thomas SA, Talbot EJ, Bennett EJ, Starza-Smith A, Da Silva SL. Cerebellar Mutism: The rehabilitation challenge in pediatric neuro-oncology: Case studies. J Pediatr Rehabil Med 2014; 7(4): 333-40.

Vassal G, Fitzgerald E, Schrappe M, et al. Challenges for children and adolescents with cancer in Europe: the SIOP-Europe agenda. Pediatr Blood Cancer 2014; 61(9): 1551-7.

Spence T, Sin-Chan P, Picard D, et al. CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta neuropathologica 2014; 128(2): 291-303.

Smith SJ, Rahman CV, Clarke PA, et al. Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma. Annals of the Royal College of Surgeons of England 2014; 96(7): 495-501.

Rodriguez Gutierrez D, Awwad A, Meijer L, et al. Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. AJNR American journal of neuroradiology 2014; 35(5): 1009-15.

Perry C, Agarwal D, Abdel-Fatah TM, et al. Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era. Oncotarget 2014.

Othman RT, Kimishi I, Bradshaw TD, et al. Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta neuropathologica communications 2014; 2: 57.

Orphanidou-Vlachou E, Vlachos N, Davies NP, Arvanitis TN, Grundy RG, Peet AC. Texture analysis of T1 - and T2 -weighted MR images and use of probabilistic neural network to discriminate posterior fossa tumours in children. NMR Biomed 2014; 27(6): 632-9.

Oberthuer A, Juraeva D, Hero B, et al. Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers. Clinical cancer research : an official journal of the American Association for Cancer Research 2014.

Lindsey JC, Kawauchi D, Schwalbe EC, et al. Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance. Oncogene 2014.

Lagah S, Tan IL, Radhakrishnan P, et al. RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PloS one 2014; 9(1): e86187.

Ju YS, Alexandrov LB, Gerstung M, et al. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. eLife 2014; 3.

Ivanov DP, Parker TL, Walker DA, et al. Multiplexing spheroid volume, resazurin and Acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres. PloS one 2014; 9(8): e103817.

Glaser A, Nicholson J, Taylor R, Walker D. Childhood cancer and proton beam therapy. BMJ 2014; 349: g5654.
de Kock L, Sabbaghian N, Druker H, et al. Germ-line and somatic DICER1 mutations in pineoblastoma. Acta neuropathologica 2014.

Cooke SL, Shlien A, Marshall J, et al. Processed pseudogenes acquired somatically during cancer development. Nature communications 2014; 5: 3644.

Carvalho D, Mackay A, Bjerke L, et al. The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma. Acta neuropathologica communications 2014; 2(1): 23. 




Wilson M, Cummins C, Macpherson L, Sun Y, Natarajan K, Grundy R, Arvanitis T, Kauppinen R, AC P. Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours. European Journal of Cancer. 2013;49(2):457-64.

Wilne S, Dineen R, Dommett R, Chu T, Walker D. Identifying brain tumours in children and young adults. British Medical Journal. 2013;347:f5844.

Walker DA, Liu J, Kieran M, Jabado N, Picton S, Packer R, St Rose C. A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method. Neuro Oncol. 2013 Apr;15(4):462-8. PubMed PMID: 23502427. Pubmed Central PMCID: PMC3607269. Epub 2013/03/19. eng.

Vicente J, Fuster-Garcia E, Tortajada S, García-Gómez J, Davies N, Natarajan K, Wilson M, Grundy R, Wesseling P, Monleón D, Celda B, Robles M, AC P. Accurate classification of childhood brain tumours by in vivo(1)H MRS - A multi-centre study. European Journal of Cancer. 2013;49(3):658-67.

Tan C, Scotting P. Stem cell research points the way to the cell of origin for intracranial germ cell tumours. Journal of Pathology. 2013;229(1):4-11.

Smith S, Wilson M, Ward J, Rahman C, Peet A, Macarthur D, Rose F, Grundy R, Rahman R. Recapitulation of Tumor Heterogeneity and Molecular Signatures in a 3D Brain Cancer Model with Decreased Sensitivity to Histone Deacetylase Inhibition. 2013.

Schwalbe EC, Hayden JT, Rogers HA, Miller S, Lindsey JC, Hill RM, Nicholson SL, Kilday JP, Adamowicz-Brice M, Storer L, Jacques TS, Robson K, Lowe J, Williamson D, Grundy RG, Bailey S, Clifford SC. Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types. Acta neuropathologica. 2013 Dec;126(6):943-6. PubMed PMID: 24212602. Epub 2013/11/12. eng.

Rogers HA, Ward JH, Miller S, Lowe J, Coyle B, Grundy RG. The role of the WNT/beta-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs). Br J Cancer. 2013 May 28;108(10):2130-41. PubMed PMID: 23591193. Pubmed Central PMCID: PMC3670474. Epub 2013/04/18. eng.

Rogers HA, Mayne C, Chapman RJ, Kilday JP, Coyle B, Grundy RG. PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Dec 1;19(23):6450-60. PubMed PMID: 24077346. Epub 2013/10/01. eng.

Rodriguez Gutierrez D, Manita M, Jaspan T, Dineen RA, Grundy RG, Auer DP. Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics. Neuro Oncol. 2013 Aug;15(8):981-9. PubMed PMID: 23585630. Pubmed Central PMCID: PMC3714149. Epub 2013/04/16. eng.

Rodriguez Gutierrez D, Awwad A, Meijer L, Manita M, Jaspan T, Dineen RA, Grundy RG, Auer DP. Metrics and Textural Features of MRI Diffusion to Improve Classification of Pediatric Posterior Fossa Tumors. AJNR American journal of neuroradiology. 2013 Dec 5. PubMed PMID: 24309122. Epub 2013/12/07. Eng.

Rahman CV, Smith SJ, Morgan PS, Langmack KA, Clarke PA, Ritchie AA, Macarthur DC, Rose FR, Shakesheff KM, Grundy RG, Ruman R. Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PloS one. 2013;8(10):e77435. PubMed PMID: 24155955. Pubmed Central PMCID: PMC3796488. Epub 2013/10/25. eng.

Orphanidou-Vlachou E, Auer D, Brundler MA, Davies NP, Jaspan T, MacPherson L, Natarajan K, Sun Y, Arvanitis TN, Grundy RG, Peet AC. (1)H magnetic resonance spectroscopy in the diagnosis of paediatric low grade brain tumours. European journal of radiology. 2013 Jun;82(6):e295-301. PubMed PMID: 23489978. Epub 2013/03/16. eng.

Miller S, Ward JH, Rogers HA, Lowe J, Grundy RG. Loss of INI1 Protein Expression Defines a Subgroup of Aggressive Central Nervous System Primitive Neuroectodermal Tumors. Brain Pathology. 2013;23(1):19-27.

Henriquez NV, Forshew T, Tatevossian R, Ellis M, Richard-Loendt A, Rogers H, Jacques TS, Reitboeck PG, Pearce K, Sheer D, Grundy RG, Brandner S. Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro. Cancer Res. 2013 Sep 15;73(18):5834-44. PubMed PMID: 23887970. Epub 2013/07/28. eng.

Grill J, Geoerger B, Gesner L, Perek D, Leblond P, Canete A, Aerts I, Madero L, de Toledo Codina JS, Verlooy J, Estlin E, Cisar L, Breazna A, Dorman A, Bailey S, Nicolin G, Grundy RG, Hargrave D. Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study. Neuro Oncol. 2013 Sep;15(9):1236-43. PubMed PMID: 23857707. Pubmed Central PMCID: PMC3748925. Epub 2013/07/17. eng.

Fetit AE, Novak J, Rodriguez D, Auer DP, Clark CA, Grundy RG, Jaspan T, Peet AC, Arvanitis TN. MRI texture analysis in paediatric oncology: a preliminary study. Studies in health technology and informatics. 2013;190:169-71. PubMed PMID: 23823412. Epub 2013/07/05. eng.

Cusack M, Scotting P. DNA mthylation in germ cell tumour aetiology: current understanding and outstanding questions. Reproduction. 2013;146(2):R49-60.



Wilne S, Collier J, Kennedy C, Jenkins A, Grout J, Mackie S, Koller K, Grundy R and Walker D. Progression from first symptom to diagnosis in childhood brain tumours. European Journal of Pediatrics 2012;171(1):87-93

Osorno R, Tsakiridis A, Wong F, Cambray N, Economou C, Wilkie R, Blin G, Scotting PJ, Chambers I, Wilson V. The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Development 2012;139(13):2288-98.

Tan T, Rahman R, Jaber Hijazi F, Felix D, Chen C, Louis E, and Aboobaker A. Telomerase activity in adult stem cells is adapted to an immortal life history in obligate asexual worms. Proceedings of the National Academy of Sciences USA 2012;109:4209-4214.

Smith SJ, Wilson M, Ward JH, Rahman CV, Peet AC, Macarthur DC, Rose FRAJ, Grundy RG, Rahman R. A dynamic 3D brain cancer model recapitulates neoplastic phenotypes and molecular signatures with decreased sensitivity to histone deacetylase inhibition. PLoS One 2012;7(12).

Picard D, Miller S, Hawkins CE, Bouffet E, Rogers HA, Chan TS, Kim SK, Ra YS, Fangusaro J, Korshunov A, Toledano H, Nakamura H, Hayden JT, Chan J, Lafay-Cousin L, Hu P, Fan X, Muraszko KM, Pomeroy SL, Lau CC, Ng HK, Jones C, Van Meter T, Clifford SC, Eberhart C, Gajjar A, Pfister SM, Grundy RG, Huang A. Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. Lancet Oncol. 2012;13(8):838-48.

Kilday JP, Mitra B, Domerg C, Ward J, Andreiuolo F, Osteso-Ibanez T, Mauguen A, Varlet P, Le Deley MC, Lowe J, Ellison DW, Gilbertson RJ, Coyle B, Grill J, Grundy RG. Copy number gain of 1q25 predicts poor progression-free survival for pediatric intracranial ependymomas and enables patient risk stratification: a prospective European clinical trial cohort analysis on behalf of the Children's Cancer Leukaemia Group (CCLG), Societe Francaise d'Oncologie Pediatrique (SFOP), and International Society for Pediatric Oncology (SIOP). Clin Cancer Res. 2012;18(7):2001-11.

Smith SJ, Tilly H, Ward JH, Macarthur DC, Lowe J, Coyle B, Grundy RG. CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma. Acta Neuropathol 2012;124(1):99-110.

Rogers HA, Sousa S, Salto C, Arenas E, Coyle B, and Grundy RG (2012) WNT/β catenin pathway activation in Myc immortalized cerebellar progenitor cells inhibits neuronal differentiation and generates tumors resembling medulloblastoma. British Journal of Cancer 2012;107(7):1144-52

Rogers HA, Kilday JP, Mayne C, Ward J, Adamowicz-Brice M, Schwalbe E, Clifford SC, Coyle B, Grundy RG (2012) Supratentorial and spinal ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Acta Neuropathol 2012;123(5):711-25




Davis EE, Pitchford NJ, Jaspan T, McArthur DC, Walker DA: Effects of hydrocephalus after cerebellar tumor: A case-by-case approach. Pediatr Neurol 2011;44:193-201.

Ellison DW, Kocak M, Figarella-Branger D, Felice G, Catherine G, Pietsch T, Frappaz D, Massimino M, Grill J, Boyett JM, Grundy RG: Histopathological grading of pediatric ependymoma: Reproducibility and clinical relevance in european trial cohorts. J Negat Results Biomed 2011;10:7.

Grundy R: The development of cell line models of childhood brain tumours. Altern Lab Anim 2011;38 Suppl 1:11-13.

Hussein D, Punjaruk W, Storer LC, Shaw L, Ottoman R, Peet A, Miller S, Bandopadhyay G, Heath R, Kumari R, Bowman KJ, Braker P, Rahman R, Jones GD, Watson S, Lowe J, Kerr ID, Grundy RG, Coyle B: Pediatric brain tumor cancer stem cells: Cell cycle dynamics, DNA repair, and etoposide extrusion. Neuro Oncol 2011;13:70-83.

Rahman R, Grundy R: Histone deacetylase inhibition as an anticancer telomerase-targeting strategy. Int J Cancer 2011

Tai BC, Grundy R, Machin D: On the importance of accounting for competing risks in pediatric brain cancer: Ii. Regression modeling and sample size. Int J Radiat Oncol Biol Phys 2011;79:1139-1146.

Walker DA, Finlay J: Central nervous system tumors of childhood and adolescence: The rehabilitation challenge of survival and "True cure". J Pediatr Rehabil Med 2011;4:23-29.

Wilne S, Collier J, Kennedy C, Jenkins A, Grout J, Mackie S, Koller K, Grundy R, Walker D: Progression from first symptom to diagnosis in childhood brain tumours. Eur J Pediatr 2011

Jeyapalan JN, Noor DA, Lee SH, Tan CL, Appleby VA, Kilday JP, Palmer RD, Schwalbe EC, Clifford SC, Walker DA, Murray MJ, Coleman N, Nicholson JC, Scotting PJ: Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance. Br J Cancer In press




Barrow J, Adamowicz-Brice M, Cartmill M, MacArthur D, Lowe J, Robson K, Brundler MA, Walker DA, Coyle B, Grundy R: Homozygous loss of adam3a revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. Neuro Oncol 2010;13:212-222. 

Conroy S, Garnett M, Vloeberghs M, Grundy R, Craven I, Walker D: Medulloblastoma in childhood: Revisiting intrathecal therapy in infants and children. Cancer Chemother Pharmacol 2010;65:1173-1189.

Davies NP, Wilson M, Natarajan K, Sun Y, MacPherson L, Brundler MA, Arvanitis TN, Grundy RG, Peet AC: Non-invasive detection of glycine as a biomarker of malignancy in childhood brain tumours using in-vivo 1h mrs at 1.5 tesla confirmed by ex-vivo high-resolution magic-angle spinning nmr. NMR Biomed 2010;23:80-87.

Davis E, Pitchford N, Jaspan T, Macarthur D, Walker D: Development of cognitive and motor function following cerebellar tumour injury sustained in early childhood. Cortex 2010;46:919-932.

Grundy R, Walker D: Brain and spinal tumours: Contemporary challenges inc linical practice. Paediatrics & Child Health 2010;20:117-122.

Grundy RG, Wilne SH, Robinson KJ, Ironside JW, Cox T, Chong WK, Michalski A, Campbell RH, Bailey CC, Thorp N, Pizer B, Punt J, Walker DA, Ellison DW, Machin D, Children's C, Leukaemia Group Brain Tumour C, Campbell RHA: Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: Results of the first ukccsg/siop cns 9204 trial. European Journal of Cancer 2010;46:120-133.

Hawley D, Walker D: A symptomatic journey to the centre of the brain. Archives of Disease in Childhood Education & Practice Edition 2010;95:59-64.

Hussein D, Punjaruk W, Storer LC, Shaw L, Ottoman R, Peet A, Miller S, Bandopadhyay G, Heath R, Kumari R, Bowman KJ, Braker P, Rahman R, Jones GD, Watson S, Lowe J, Kerr ID, Grundy RG, Coyle B: Pediatric brain tumor cancer stem cells: Cell cycle dynamics, DNA repair, and etoposide extrusion. Neuro Oncol 2010;13:70-83.

Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang YD, Coyle B, Atkinson J, DeWire M, Kranenburg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison DW, Taylor MD, Grundy RG, Gilbertson RJ: Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 2010;466:632-636.

Lee SH, Appleby V, Jeyapalan JN, Palmer RD, Nicholson JC, Sottile V, Gao E, Coleman N, Scotting PJ: Variable methylation of the imprinted gene, snrpn, supports a relationship between intracranial germ cell tumours and neural stem cells. J Neurooncol 2010;101:419-428.

Lee SH, Jeyapalan JN, Appleby V, Mohamed Noor DA, Sottile V, Scotting PJ: Dynamic methylation and expression of oct4 in early neural stem cells. J Anat 2010;217:203-213.

Michalski A, Bouffet E, Taylor R, Hargrave D, Walker D, Picton S, Robinson K, Pizer B, Bujkiewicz S: The addition of high dose tamoxifen to standard radiotherapy does not improve the survival of patients with diffuse intrinsic pontine glioma. Journal of Neuro Oncology 2010;100:81-88.

Oberthuer A, Hero B, Berthold F, Juraeva D, Faldum A, Kahlert Y, Asgharzadeh S, Seeger R, Scaruffi P, Tonini GP, Janoueix-Lerosey I, Delattre O, Schleiermacher G, Vandesompele J, Vermeulen J, Speleman F, Noguera R, Piqueras M, Benard J, Valent A, Avigad S, Yaniv I, Weber A, Christiansen H, Grundy RG, Schardt K, Schwab M, Eils R, Warnat P, Kaderali L, Simon T, Decarolis B, Theissen J, Westermann F, Brors B, Fischer M: Prognostic impact of gene expression-based classification for neuroblastoma. J Clin Oncol 2010;28:3506-3515.

Paugh BS, Qu C, Jones C, Liu Z, Adamowicz-Brice M, Zhang J, Bax DA, Coyle B, Barrow J, Hargrave D, Lowe J, Gajjar A, Zhao W, Broniscer A, Ellison DW, Grundy RG, Baker SJ: Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J Clin Oncol 2010;28:3061-3068.

Rahman R, Osteso-Ibanez T, Hirst RA, Levesley J, Kilday JP, Quinn S, Peet A, O'Callaghan C, Coyle B, Grundy RG: Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high-grade childhood brain tumor cells. Mol Cancer Ther 2010;9:2568-2581.

Rahman R, Smith S, Rahman C, Grundy R: Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma. J Oncol 2010;2010:251231.

Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D, Giangaspero F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J: Survival and prognostic factors of early childhood medulloblastoma: An international meta-analysis. J Clin Oncol 2010;28:4961-4968.

Stokland T, Liu JF, Ironside JW, Ellison DW, Taylor R, Robinson KJ, Picton SV, Walker DA: A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: A population-based cohort study (cclg cns9702). Neuro Oncol 2010;12:1257-1268.

Tai BC, Grundy RG, Machin D: On the importance of accounting for competing risks in pediatric cancer trials designed to delay or avoid radiotherapy: I. Basic concepts and first analyses. Int J Radiat Oncol Biol Phys 2010;76:1493-1499.

Wilne S, Koller K, Collier J, Kennedy C, Grundy R, Walker D: The diagnosis of brain tumours in children: A guide to assist healthcare professionals in the assessment of children who may have a brain tumour. Archives of Disease in Childhood Education & Practice Edition 2010;10.1136/adc.2009.162057

Wilne S, Walker D: Spine and spinal cord tumours in children: A diagnostic and therapeutic challenge to healthcare systems. Archives of Disease in Childhood Education & Practice Edition 2010;95:47-54.




Davies N, Wilson M, Natarajan K, Sun Y, Macpherson L, Brundler MA, Arvanitis TN, Grundy R, Peet AC: Non-invasive detection of glycine as a biomarker of malignancy in childhood brain tumours using in-vivo (1)h mrs at 1.5 tesla confirmed by ex-vivo high-resolution magic-angle spinning nmr. NMR Biomed 2009;23:80-87.

Kilday JP, Rahman R, Dyer S, Ridley L, Lowe J, Coyle B, Grundy R: Pediatric ependymoma: Biological perspectives. Mol Cancer Res 2009;7:765-786.

Messahel B, Ashley S, Saran F, Ellison D, Ironside J, Phipps K, Cox T, Chong WK, Robinson K, Picton S, Pinkerton CR, Mallucci C, Macarthur D, Jaspan T, Michalski A, Grundy RG: Relapsed intracranial ependymoma in children in the uk: Patterns of relapse, survival and therapeutic outcome. Eur J Cancer 2009;45:1815-1823.

Northcott PA, Fernandez LA, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD: The mir-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by n-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res 2009;69:3249-3255.

Northcott PA, Nakahara Y, Wu X, Feuk L, Ellison DW, Croul S, Mack S, Kongkham PN, Peacock J, Dubuc A, Ra YS, Zilberberg K, McLeod J, Scherer SW, Sunil Rao J, Eberhart CG, Grajkowska W, Gillespie Y, Lach B, Grundy R, Pollack IF, Hamilton RL, Van Meter T, Carlotti CG, Boop F, Bigner D, Gilbertson RJ, Rutka JT, Taylor MD: Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet 2009;41:465-472.

Rahman R, Heath R, Grundy R: Cellular immortality in brain tumours: An integration of the cancer stem cell paradigm. Biochim Biophys Acta 2009;1792:280-288.

Rogers HA, Miller S, Lowe J, Brundler MA, Coyle B, Grundy RG: An investigation of wnt pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (cns pnet). Br J Cancer 2009;100:1292-1302.

Taylor RE, Donachie PH, Weston CL, Robinson KJ, Lucraft H, Saran F, Ellison DW, Ironside J, Walker DA, Pizer BL, Children's C, Leukaemia Group CNSTD, Taylor RE, Donachie PHJ, Weston CL, Robinson KJ, Lucraft H, Saran F, Ellison DW, Ironside J, Walker DA, Pizer BL: Impact of radiotherapy parameters on outcome for patients with supratentorial primitive neuro-ectodermal tumours entered into the siop/ukccsg pnet 3 study. Radiother Oncol 2009;92:83-88.

Walker D, Pearman D: Therapeutic recreation camps: An effective intervention for children and young people with chronic illness? Archives of Disease in Childhood 2009;94:401-406.

Wilson M, Davies NP, Brundler MA, McConville C, Grundy RG, Peet AC: High resolution magic angle spinning 1h nmr of childhood brain and nervous system tumours. Mol Cancer 2009;8:6.

Wilson M, Davies NP, Grundy RG, Peet AC: A quantitative comparison of metabolite signals as detected by in vivo mrs with ex vivo 1h hr-mas for childhood brain tumours. NMR Biomed 2009;22:213-219.

Wilson S, Grundy R, Vyas H: Investigation and management of a child who is immunocompromised and neutropoenic with pulmonary infiltrates. Arch Dis Child Educ Pract Ed 2009;94:129-137.




Baumforth KR, Birgersdotter A, Reynolds GM, Wei W, Kapatai G, Flavell JR, Kalk E, Piper K, Lee S, Machado L, Hadley K, Sundblad A, Sjoberg J, Bjorkholm M, Porwit AA, Yap LF, Teo S, Grundy RG, Young LS, Ernberg I, Woodman CB, Murray PG: Expression of the epstein-barr virus-encoded epstein-barr virus nuclear antigen 1 in hodgkin's lymphoma cells mediates up-regulation of ccl20 and the migration of regulatory t cells. Am J Pathol 2008;173:195-204. 

Clayton J, Vloeberghs M, Jaspan T, Walker D, MacArthur D, Grundy R: Intrathecal chemotherapy delivered by a lumbar-thecal catheter in metastatic medulloblastoma: A case illustration. Acta Neurochir (Wien) 2008;150:709-712.

Davies NP, Wilson M, Harris LM, Natarajan K, Lateef S, Macpherson L, Sgouros S, Grundy RG, Arvanitis TN, Peet AC: Identification and characterisation of childhood cerebellar tumours by in vivo proton mrs. NMR Biomed 2008;21:908-918.

Harris LM, Davies NP, Macpherson L, Lateef S, Natarajan K, Brundler MA, Sgouros S, English MW, Arvanitis TN, Grundy RG, Peet AC: Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas. Eur J Cancer 2008;44:2640-2647.

Howden L, Giddings D, Power H, Aroussi A, Vloeberghs M, Garnett M, Walker D: Three-dimensional cerebrospinal fluid flow within the human ventricular system. Computer Methods in Biomechanics & Biomedical Engineering 2008;11:123-133.

Peet AC, Arvanitis TN, Auer DP, Davies NP, Hargrave D, Howe FA, Jaspan T, Leach MO, Macarthur D, MacPherson L, Morgan PS, Natarajan K, Payne GS, Saunders D, Grundy RG: The value of magnetic resonance spectroscopy in tumour imaging. Arch Dis Child 2008;93:725-727.

Rand V, Prebble E, Ridley L, Howard M, Wei W, Brundler MA, Fee BE, Riggins GJ, Coyle B, Grundy RG: Investigation of chromosome 1q reveals differential expression of members of the s100 family in clinical subgroups of intracranial paediatric ependymoma. Br J Cancer 2008;99:1136-1143.

Ridley L, Rahman R, Brundler MA, Ellison D, Lowe J, Robson K, Prebble E, Luckett I, Gilbertson RJ, Parkes S, Rand V, Coyle B, Grundy RG: Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. Neuro Oncol 2008;10:675-689.

Shaikh MG, Grundy RG, Kirk JM: Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothalamic damage in children. Eur J Endocrinol 2008;159:791-797.

Shaikh MG, Grundy RG, Kirk JM: Reductions in basal metabolic rate and physical activity contribute to hypothalamic obesity. J Clin Endocrinol Metab 2008;93:2588-2593.

Traunecker H, Mallucci C, Grundy R, Pizer B, Saran F: Children's cancer and leukaemia group (cclg): Guidelines for the management of intracranial meningioma in children and young people. Br J Neurosurg 2008;22:13-25; discussion 24-15.




Bose S, Starczynski J, Chukwuma M, Baumforth K, Wei W, Morgan S, Byrd P, Ying J, Grundy R, Mann JR, Tao Q, Taylor AM, Murray PG, Stankovic T: Down-regulation of atm protein in hrs cells of nodular sclerosis hodgkin's lymphoma in children occurs in the absence of atm gene inactivation. J Pathol 2007;213:329-336.

Grundy R: Primary radiotherapy for childhood ependymoma? Lancet Oncology 2007;8:760-761.

Grundy RG, Wilne SA, Weston CL, Robinson K, Lashford LS, Ironside J, Cox T, Chong WK, Campbell RH, Bailey CC, Gattamaneni R, Picton S, Thorpe N, Mallucci C, English MW, Punt JA, Walker DA, Ellison DW, Machin D: Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: The ukccsg/siop prospective study. Lancet Oncol 2007;8:696-705.

Harris LM, Davies N, Macpherson L, Foster K, Lateef S, Natarajan K, Sgouros S, Brundler MA, Arvanitis TN, Grundy RG, Peet AC: The use of short-echo-time 1h mrs for childhood cerebellar tumours prior to histopathological diagnosis. Pediatr Radiol 2007;37:1101-1109.

Hyatt M, Budge H, Walker D, Stephenson T, Symonds M: Effects of maternal parity and late gestational nutrition on mrna abundance for growth factors in the liver of postnatal sheep. American Journal of Physiology: Regulatory, Intergrative & Comparative Physiology 2007;292:R1934-R1942.

Hyatt M, Budge H, Walker D, Stephenson T, Symonds M: Ontogeny and nutritional programming of the hepatic grwoth hormone-insulin-like growth factor-prolactin axis in the sheep. Endocrinology 2007;148:4754-4760.

Hyatt M, Gopalakrishnan G, Bispham J, Gentili S, McMillen I, Rhind S, Rae M, Kyle C, Brooks A, Jones C, Budge H, Walker D, Stephenson T, Symonds M: Maternal nutrient restriction in early pregnancy programs hepatic mrna expression of growth-related genes and liver size in adult male sheept. Journal of Endocrinology 2007;192:87-97.

Kombogiorgas D, Sgouros S, Walsh AR, Hockley AD, Stevens M, Grundy R, Peet A, English M, Spooner D: Outcome of children with posterior fossa medulloblastoma: A single institution experience over the decade 1994-2003. Childs Nerv Syst 2007;23:399-405.

McManamy CS, Pears J, Weston CL, Hanzely Z, Ironside JW, Taylor RE, Grundy RG, Clifford SC, Ellison DW: Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior. Brain Pathol 2007;17:151-164.

Meng W, Kallinteri P, Walker D, Parker T, Garnett M: Evaluation of poly (glycerol-adipate) nanoparticle uptake in an in vitro 3-d brain tumour co-culture model. Experimental Biology & Medicine 2007;232:1100-1108.

Ng A, Griffiths A, Cole T, Davison V, Griffiths M, Larkin S, Parkes SE, Mann JR, Grundy RG: Congenital abnormalities and clinical features associated with wilms' tumour: A comprehensive study from a centre serving a large population. Eur J Cancer 2007;43:1422-1429.

Peet AC, Davies NP, Ridley L, Brundler MA, Kombogiorgas D, Lateef S, Natarajan K, Sgouros S, MacPherson L, Grundy RG: Magnetic resonance spectroscopy suggests key differences in the metastatic behaviour of medulloblastoma. Eur J Cancer 2007;43:1037-1044.

Peet AC, Lateef S, MacPherson L, Natarajan K, Sgouros S, Grundy RG: Short echo time 1 h magnetic resonance spectroscopy of childhood brain tumours. Childs Nerv Syst 2007;23:163-169.

Peet AC, McConville C, Wilson M, Levine BA, Reed M, Dyer SA, Edwards EC, Strachan MC, McMullan DJ, Wilkes TM, Grundy RG: 1h mrs identifies specific metabolite profiles associated with mycn-amplified and non-amplified tumour subtypes of neuroblastoma cell lines. NMR Biomed 2007;20:692-700.

Wilne S, Collier J, Kennedy C, Koller K, Grundy R, Walker D: Presentation of childhood cns tumours: A systematic review and meta-analysis. Lancet Oncol 2007;8:685-695.




Chantada G, Doz F, Antoneli CB, Grundy R, Clare Stannard FF, Dunkel IJ, Grabowski E, Leal-Leal C, Rodriguez-Galindo C, Schvartzman E, Popovic MB, Kremens B, Meadows AT, Zucker JM: A proposal for an international retinoblastoma staging system. Pediatr Blood Cancer 2006;47:801-805.

Langdon JA, Lamont JM, Scott DK, Dyer S, Prebble E, Bown N, Grundy RG, Ellison DW, Clifford SC: Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma. Genes Chromosomes Cancer 2006;45:47-60.

Meng W, Parker T, Kallinteri P, Walker D, Higgins S, Hutcheon G, Garnett M: Uptake and metabolism of novel biodegradable poly(glycerol-adipate) nanoparticles in daoy monolayer. Journal of Controlled Release 2006;116:314-321.

Mitchell C, Pritchard-Jones K, Shannon R, Hutton C, Stevens S, Machin D, Imeson J, Kelsey A, Vujanic GM, Gornall P, Walker J, Taylor R, Sartori P, Hale J, Levitt G, Messahel B, Middleton H, Grundy R, Pritchard J: Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic wilms' tumour: Results of a randomised trial (ukw3) by the uk children's cancer study group. Eur J Cancer 2006;42:2554-2562.

Pizer B, Weston C, Robinson K, Ellison D, Ironside J, Saran F, Lashford L, Tait D, Lucraft H, Walker D, Bailey C, Taylor R: Analysis of patients with supratentorial primitive neuro-ectodermal tumours entered into the siop/ukccsg pnet 3 study. European Journal of Cancer 2006;42:1120-1128.

Scotting P: Are cranial germ cell tumours really tumours of germ cells? Neuropath App Neurobiol 2006;32:569-574.

Sharif K, Ramani P, Lochbuhler H, Grundy R, de Ville de Goyet J: Recurrent mesenchymal hamartoma associated with 19q translocation. A call for more radical surgical resection. Eur J Pediatr Surg 2006;16:64-67.

Sottile V, Li M, Scotting P: Stem cell marker expression in the bergmann glia population of the adult mouse brain. Brain Research 2006;1099:8-17.

Thompson HJ, Marklund N, LeBold DG, Morales DM, Keck CA, Vinson M, Royo NC, Grundy R, McIntosh TK: Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody. Eur J Neurosci 2006;24:3063-3072.




Astuti D, Latif F, Wagner K, Gentle D, Cooper WN, Catchpoole D, Grundy R, Ferguson-Smith AC, Maher ER: Epigenetic alteration at the dlk1-gtl2 imprinted domain in human neoplasia: Analysis of neuroblastoma, phaeochromocytoma and wilms' tumour. Br J Cancer 2005;92:1574-1580. 

Chantada G, Doz F, Antoneli C, Grundy R, Clare Stannard F, Dunkel I, Grabowski E, Leal-Leal C, Rodriguez-Galindo C, Schvartzman E, Popovic M, Kremens B, Meadows A, Zucker J: A proposal for an international retinoblastoma staging system. Pediatic Blood Cancer 2005

Cooper WN, Luharia A, Evans GA, Raza H, Haire AC, Grundy R, Bowdin SC, Riccio A, Sebastio G, Bliek J, Schofield PN, Reik W, Macdonald F, Maher ER: Molecular subtypes and phenotypic expression of beckwith-wiedemann syndrome. Eur J Hum Genet 2005;13:1025-1032.

Kallinteri P, Higgins S, Hutcheon G, St Pourcain C, Garnett M: Novel functionalised biodegradable polymers for nanoparticle drug delivery systems. Biomacromolecules 2005;6:1885-1894.

Kordes U, Cheng Y-C, Scotting P: Sox group e gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse. Developmental Brain Research 2005;157:209-213.

Lee C-J, Chan W-I, Scotting P: Cic, a gene involved in cerebellar development and erbb signalling, is significantly expressed in medulloblastomas. Journal of Neuro Oncology 2005;73:101-108.

Meng W, Parker T, Kallinteri P, Hutcheon G, Higgins S, Walker D, Garnett M: Uptake and drug delivery using biodegradable nanoparticles in monolayers and organotypic brain slices. Neuro-Oncology 2005;7:383.

Ng A, Jenkinson H, Morland B, Grundy R: Clear cell sarcoma: A dilemma on pathological staging and clinical management. Pediatr Hematol Oncol 2005;22:257-261.

Ng A, Nishikawa H, Lander A, Grundy R: Chemosensitivity in pediatric dermatofibrosarcoma protuberans. J Pediatr Hematol Oncol 2005;27:100-102.

Parker T, Searle K, Storer L, Walker D: Regional brain spheroid culture: An in vitro 3d model to study specificity of tumour invasion. Neuro-Oncology 2005;7:306.

Peet AC, Leach MO, Pinkerton CR, Price P, Williams SR, Grundy RG: The development of functional imaging in the diagnosis, management and understanding of childhood brain tumours. Pediatr Blood Cancer 2005;44:103-113.

Savill R, Scotting P, Coyle E: Strategies to investigate gene expression and function in granule cells. Cerebellum 2005;4:1-8.

Scotting P, Walker D, Perilongo G: Childhood solid tumours: A developmental disorder. Nature Reviews/Cancer 2005;5:481-488.

Seale C, Kirk D, Tobin M, Burton P, Grundy R, Pritchard-Jones K, Dixon-Woods M: Effect of media portrayals of removal of children's tissue on uk tumour bank. BMJ 2005;331:401-403.

Storer L, Loku Kalutotage A, Walker D, Parker T: The comparable effect of exo- and endogenous cannabinoids on apoptosis in human medullobastoma and rat glioma cells. Neuro-Oncology 2005;7:376.

Walker D: Adolescent cns tumours: My brain has damaged my life; in Eden T, Barr R, Bleyer A (eds): Cancer and the adolescent. Oxford, Blackwell Publishing, 2005

Walker D, Ammourah S, Aroussi A, Garnett M, Giddings D, Howden L, Power H, Vloeberghs M: Physical and numerical modeling cerebrospinal fluid behavior for drug delivery to the leptomeninges. Neuro-Oncology 2005;7:308.

Walker D, Bailey C, Taylor R, Perilongo G, Punt J: Pediatric neuro-oncology from 2500 bc to now: A historical perspective. Neuro-Oncology 2005;7:374.

Walker D, C S, Ries L, Bleyer A, Bendel A: Age-related patterns in cns tumor incidence with a focus on the adolescent and young adult population. Neuro-Oncology 2005;7:305.

Walker D, Wilne S: Treatment of medulloblastoma in young children. The Lancet Oncology 2005;6:541-542.

Wilne S, Collier J, Walker D, Grundy R, Kennedy C, Punt J: The presentation of childhood brain tumors: A meta-analysis. Neuro-Oncology 2005;7:335.




Aroussi, Vloeberghs M, Etchell S, Grandsden J, Latimer R, Giddings D: Simualtion of human cerebrospinal gluid: 11th International Symposium on flow visualization. Indiana, USA, 2004,

Brennan B, Foot A, Stiller C, Kelsey A, Vujanic G, Grundy R, Pritchard-Jones K: Where to next with extracranial rhabdoid tumours in children. European Journal of Cancer 2004;40:624-626.

Grundy RG, Hutton C, Middleton H, Imeson J, Pritchard J, Kelsey A, Marsden HB, Vujanic GM, Taylor RE:Outcome of patients with stage iii or inoperable wt treated on the second united kingdom wt protocol (ukwt2); a united kingdom children's cancer study group (ukccsg) study. Pediatr Blood Cancer 2004;42:311-319.

Hyatt M, Walker D, Stephenson T, Symonds M: Ontogeny and nutritional manipulation of the hepatic prolactin-growth hormone-insulin-like growth factor axis in the ovine fetus and in neonate and juvenile sheep. Proceedings of the Nutrition Society 2004;63:127-135.

Murray PG, Qiu GH, Fu L, Waites ER, Srivastava G, Heys D, Agathanggelou A, Latif F, Grundy RG, Mann JR, Starczynski J, Crocker J, Parkes SE, Ambinder RF, Young LS, Tao Q: Frequent epigenetic inactivation of the rassf1a tumor suppressor gene in hodgkin's lymphoma. Oncogene 2004;23:1326-1331.

Veal G, English M, Grundy R, Shakespeare C, Glaser A, Waters F, Holden V, O'Meara A, Michalski A, Howe K, Cole S, Boddy A: Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy. Cancer Chemotherapy Pharmacology 2004;54:295-300.

Walker D, Perilongo G, Punt J, Taylor R: Brain & spinal tumors of childhood. London, Arnold, 2004.

Yang Z-J, Appleby V, Coyle E, Chan W-I, Tahmaseb M, Wigmore P, Scotting P: Novel strategy to study gene expression and function in developing cerebellar granule cells. J Neurosci Methods 2004




Lee W, Grundy R, Milford D, Taylor C, De Ville de Goyet J, McKiernan P, Beath S, Kelly D: Renal function following liver transplantation for unresectable hepatoblatoma. Paediatric Transplant 2003;7:27-. 

Mason V, McEwan, Walker D, Barrett S, James D: The use of video information in obtaining consent for female sterilisation: A randomised trial. British Journal of Obstetrics & Gynaecology 2003;110:1062-1071.

Morris M, Hesson L, Wagner K, Morgan N, Astuti D, Lees R, Cooper W, Lee J, Gentle D, Macdonald F, Kishida T, Grundy R, Yao M, Latif F, Maher E: Multigene methylation analysis of wilms' tumour and adult renal cell carcinoma. Oncogene 2003;22:6794-6801.

Patterson A, Grundy R, De Ville de Goyet J, Rafaat F, Beath S, McCarthy A: Congenital malignant peritoneal mesothelioma. Pediatric Radiology 2003;33:73-74.

Reiman A, Powell J, Flavell K, Grundy R, Mann J, Parkes S, Redfern D, Young L, Murray P: Seasonal differences in the onset of the ebv-positive and -negative forms of paediatric hodgkin's lymphoma. British Journal of Cancer 2003;89:1200-1201.

Thomas D, Pritchard J, Davidson R, McKiernan P, Grundy RG, de Ville de Goyet J: Familial hepatoblastoma and apc gene mutations: Renewed call for molecular research. Eur J Cancer 2003;39:2200-2204.

Walker D: Recent advances in optic nerve glioma with a focus on the young patient. Current Opinion in Neurology 2003;16:657-665.




Dow G, Martin K, Walker D, Punt J: Cytogenetic abnormalities in primitive neuroectodermal tumours: Have they influenced management? Child's Nervous System 2002;18:248.

Dow G, Robson D, Sokal M, Walker D, Punt J: Peripheral primitive neuroectodermal tumours involving skull and axial skeleton: Experience with four cases. Child's Nervous System 2002;18:248.

Lee C-J, Appleby V, Orme A, Chan W-I, Scotting P: Differential expression of sox4 and sox11 in medulloblastomas. Journal of Neuro Oncology 2002;57:201-214.

Lee C-J, Chan W-I, Cheung M, Cheng Y-C, Appleby V, Orme A, Scotting P: Cic, a member of a novel subfamily of the hmg-box superfamily, is transiently expressed in developing granule neurons. Molecular Brain Research 2002;106:151-156.

Nicholson J, Punt J, Hale J, Saran F, Calaminus G: Neurosurgical management of paediatric germ cell tumours of the central nervous system - a multi-disciplinary team approach for the new millennium. British Journal of Neurosurgery 2002;16:93-95.

Searle K, Punt J, Erckens G, Shepherd G, Walker D, Parker T: Migration and invasion patterns of medulloblastoma cells studies in 2- and 3-d in vitro model systems. Medical & Pediatric Oncology 2002;39:326.

Storer L, Woodward A, Parker T, Punt J, Walker D: Induction of apoptosis in transformed human medulloblastoma cells by cannabinoids. Medical & Pediatric Oncology 2002;39:326.

Walker D, Gnekow A, Perilongo G, Zanetti I: Vincristine (vcr) carboplatin (cbdca) in hypothalamic-chiasmatic glioma (hcg): A report of the international consortium on low grade glioma (ICLGG). Medical & Pediatric Oncology 2002;39:229.




Cartmill M, Hewitt M, Walker D, Lowe J, Jaspan T, Punt J: The use of chemotherapy to facilitate surgical resection in a pleomorphic xanthoastrocytoma: Experiene in a single case. Child's Nervous System 2001;17:563-566. 

Cheng Y-C, Lee C-J, Badge R, Orme A, Scotting P: Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours. Mol Brain Res 2001;92:193-200.

Gilbertson R, Hernan R, Pietsch T, Pinto L, Scotting P, Allibone R, Ellison D, Perry R, Pearso A, Lunec J: Novel erbb4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma. Genes, Chromosomes & Cancer 2001;31:288-294.

Ishii Y, Abu-Elmagd M, Scotting PJ: Sox3 expression defines a common primordium for the epibranchial placodes in chick. Developmental Biology 2001;236:344-353.




Cheng Y-C, Badge RM, Armour JA, orme AT, Lee C-J, Appleby VJ, Scotting PJ: Characterisation of sox8: A novel gene expressed in medulloblastoma. European Journal of Neuroscience 2000;12

Cheng Y-C, Cheung M, Abu-Elmagd MM, Orme A, Scotting PJ: Chick sox10, a transcription factor expressed in both early neural crest cells and central nervous system. Developmental Brain Research 2000;121:233-241.

Cheung M, Abu-Elmagd M, Clevers H, Scotting PJ: Roles of zox4 in central nervous system development. Molecular Brain Research 2000;79:180-191.

Lee C-J, Appleby VJ, Orme A, Punt JAG, Walker DA, Scotting PJ: Transcription factors expressed during normal neurogenesis also exhibit widespread and varied expression in primitive neuroectodermal tumours. Neuro-Oncology 2000;2:S19.

Scotting PJ, Thompson SL, Punt JAG, Walker DA: Paediatric brain tumours: An embryological perspective. Child's Nervous System 2000;16:261-268.

Walker DA: Vincristine and carboplatin in hypthalamic-chiasmatic low-grade glioma: Report of a study of the societe internationale oncologie pediatrique. European Journal of Pediatric Neurology 2000;4:255-262.