As one of the leaders of the Children's Brain Tumour Research Centre (CBTRC), I believe that the generation of clinically relevant hypotheses is an essential element of the Centre's integrated research programme. Travelling "in research terms" from "Bed to Bench" and back again requires close working between multi-disciplinary researchers, sharing observations from the patient experience, the health impact on populations and scientific processes of discovery. These observations, when combined in intellectual debate create new collaborations to promote a vital and dynamic programme.