Children's Brain Tumour Research Centre
Molecular neurogenesis & neuro-oncology group
The age of onset of childhood brain tumours and the different spectrum of disease in adults versus children suggests that childhood tumours arise from disorder in the normal development of the central nervous system. As part of the overall research being carried out at the Children's Brain Tumour Research Centre (CBTRC), our researchers are investigating the origin of childrens' brain tumours in the context of neuro-embryology. Detailed knowledge of early brain development has focussed interest on a rare group of tumours called germ cell tumours. We are challenging the dogma regarding this group of tumours and investigating the hypothesis that they may not be arising from misplaced germ cell progenitors, but are in fact existing neural stem cells.
Dr. Paul Scotting and the Molecular Neurogenesis Research Team
Recent publications
Sottile V, Li M, Scotting P (2006). Stem cell marker expression in the Bergmann glia population of the adult mouse brain. Brain Research 1099(1):8-17.
Scotting P. Are cranial germ cell tumours really tumours of germ cells? (2006). Neuropath App Neurobiol. 32:569-74.
Scotting P, Walker D, Perilongo G. Childhood solid tumours: a developmental disorder (2005). Nature Reviews/Cancer 5:481-8.
Lee C-J, Chan W-I, Scotting P (2005). CIC, a gene involved in cerebellar development and ErbB signalling, is significantly expressed in medulloblastomas. Journal of Neuro Oncology 73:101-8.