Children's Brain Tumour Research Centre
Our profiles
Name
Dr. Ian Kerr
Qualifications
DPhil, BSc
Position
Lecturer in Biochemistry
School/Division
School of Biomedical Sciences
Contact
| Phone: | +44 (0) 115 823 0122 |
|---|---|
| Fax: | |
| Email: | ian.kerr@nottingham.ac.uk |
| Web: | http://www.nottingham.ac.uk/~mhzidk |
Research interests
ATP binding cassette (ABC) transporters, in particular the multidrug pumps ABCG2 and ABCG1 (breast cancer research protein and P-glycoprotein respectively).
Antibiotic resistance driven by ABC proteins.
Auxin transporters in plants.
Recent publications
Chuthapisith S, Layfield R, Kerr ID, Hughes C, Eremin, O (2007). Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs. Int. J. Oncol. 30: 1545-1551.
McDevitt C, Collins RF, Conway M, Modok S, Storm J, Kerr ID, Ford RC & Callaghan R. (2006) Purification and 3-D structural analysis of oligomeric human multidrug transporter ABCG2. Structure. 14: 1623-32.
Clark R, Kerr ID and Callaghan R. (2006) Multiple drug binding sites on the R482G isoform of ABCG2. Br. J. Pharmacol. 149: 506-15.
Callaghan R, Ford RC and Kerr ID (2006) The translocation mechanism of P-glycoprotein. FEBS Letters 580: 1056-1063.
Rothnie A, Storm J, McMahon R, Taylor A, Kerr ID and Callaghan R. (2005) The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment. FEBS Letters 579: 3984-3990.
Kerr ID, Reynolds ED and Cove JH. (2005). ABC proteins and antibiotic drug resistance: is it all about transport? Biochem. Soc. Trans. 33: 1000-1002.