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Name

Dr. Beth Coyle

Qualifications

PhD Faculty of Medicine, University of Edinburgh

BSc Molecular Biology, University of Edinburgh

Position

Lecturer

School/Division

Child Health

Contact

Phone: +44 (0) 115 8230719
Fax: +44 (0) 115 8230796
Email: beth.coyle@nottingham.ac.uk
Web: http://www.cbtrc.org/beth_coyle_np

Research interests

I have two main areas of research interest. For a number of years I have been investigating the potential of apoptotic mechanisms as therapeutic targets in cancer cells. Several recent studies have identified a population of ‘cancer stem cells’ that are key to the survival of brain and other tumours. Since such cells are also believed to be drug resistant and drug resistance is a major factor in many different types of brain tumour I have established a new project aimed at determining the contribution that drug resistant cancer stem cells make to relapse of paediatric brain tumours.

 

Dr. Beth Coyle and the Molecular Analysis Team

Dr. Beth Coyle and the Molecular Anaylysis Research Team

Recent publications

Savill R, Somchand N, Joyce K, Scotting PJ and Coyle B (in preparation). The caspase independent apoptotic function of ID2 occurs autonomously of the N terminal domain.


Ridley L, Raman R, Rand V, Brundler MA, Coyle B and Grundy, RJ (in preparation) Prognostic markers in paediatric ependymoma.


Savill R, Scotting PJ, and Coyle B. (2005) Strategies to investigate gene expression and function in cerebellar granule neurons Cerebellum 4, 271-8.


Coyle B, Freathy C, Gant TW, Roberts RA, Cain K. (2003). Characterization of the Transforming Growth Factor-beta 1-induced Apoptotic Transcriptome in FaO Hepatoma Cells. Journal of Biological Chemistry 278, 5920-8.